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This article has been cited by other articles in PMC. Abstract Paracetamol acetaminophen overdose remains the leading cause of death or transplantation due to acute liver failure in many parts of the world.

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The developmental changes that occur in the liver's metabolic activity from birth to adolescence contribute to the varied sensitivity to toxins seen in the pediatric population. Hepatic drug metabolism, often with an imbalance between the generation of toxic metabolites and detoxification processes, can influence the degree of hepatotoxicity.

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Most microorganisms live in close association with the body, have a significant impact on vital functions of human physiology, on the developing of immune system, and digestion and detoxification mechanisms. A particular interest is on knowing microbiome composition and function in the healthy body and elucidation of the changes in its structure, also the complex correlations with the incidence of certain diseases.

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